Wireless Monitoring of Liver Hemodynamics In Vivo [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 570 Life sciences Biology
• Thông tin xuất bản: Bethesda, Md. : Oak Ridge, Tenn. : National Institutes of Health (U.S.) ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2014
• Mô tả vật lý: Size: Article No. e102396 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 262136
• Chủ đề: 1. 59 basic biological sciences; 2. 60 applied life sciences; 3. Liver; 4. Oxygenation; 5. Perfusion monitoring; 6. Wireless sensing

Tóm tắt

Liver transplants have their highest failure rate in the first two weeks following surgery. There are no devices for continuous, real-time monitoring of the graft, currently. Here, we present a continuous perfusion and oxygen consumption monitor based on photoplethysmography. The sensor is battery operated and communicates wirelessly with a data acquisition computer which provides the possibility of implantation provided sufficient miniaturization. In two in vivo porcine studies, the sensor tracked perfusion changes in hepatic tissue during vascular occlusions with a root mean square error (RMSE) of 0.125 mL/min/g of tissue. We show the possibility of using the pulsatile wave to measure the arterial oxygen saturation similar to pulse oximetry. This signal is used as a feedback to extract the venous oxygen saturation from the DC levels. Arterial and venous oxygen saturation changes were measured with an RMSE of 2.19 and 1.39% respectively when no vascular occlusions were induced. The resulting error increased to 2.82 and 3.83% when vascular occlusions were induced during hypoxia. These errors are similar to the resolution of the oximetry catheter used as a reference. This work is the first realization of a wireless perfusion and oxygenation sensor for continuous monitoring of hepatic perfusion and oxygenation changes.