Cervical SPECT Camera for Parathyroid Imaging [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 621.37 Testing and measurement of electrical quantities
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2012
• Mô tả vật lý: Size: 1.6 MB : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 262232
• Chủ đề: 1. 46 instrumentation related to nuclear science and technology; 2. 60 applied life sciences; 3. Czt, parathyroid, molecular imaging, gamma detector, direct detection, pinhole imaging

Tóm tắt

Primary hyperparathyroidism characterized by one or more enlarged parathyroid glands has become one of the most common endocrine diseases in the world affecting about 1 per 1000 in the United States. Standard treatment is highly invasive exploratory neck surgery called Parathyroidectomy. The surgery has a notable mortality rate because of the close proximity to vital structures. The move to minimally invasive parathyroidectomy is hampered by the lack of high resolution pre-surgical imaging techniques that can accurately localize the parathyroid with respect to surrounding structures. We propose to develop a dedicated ultra-high resolution (~ 1 mm) and high sensitivity (10x conventional camera) cervical scintigraphic imaging device. It will be based on a multiple pinhole-camera SPECT system comprising a novel solid state CZT detector that offers the required performance. The overall system will be configured to fit around the neck and comfortably image a patient.