QB1 - Stochastic Gene Regulation [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 572.87 +Chromosomes
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2012
• Mô tả vật lý: Medium: ED : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 262244
• Chủ đề: 1. 59 basic biological sciences; 2. 60 applied life sciences; 3. Amplification; 4. Approximations; 5. Damping; 6. Educational facilities; 7. Et al; 8. Fluctuations; 9. Gene regulation; 10. Kinetics; 11. Quantization

Tóm tắt

 Summaries of this presentation are: (1) Stochastic fluctuations or 'noise' is present in the cell - Random motion and competition between reactants, Low copy, quantization of reactants, Upstream processes
  (2) Fluctuations may be very important - Cell-to-cell variability, Cell fate decisions (switches), Signal amplification or damping, stochastic resonances
  and (3) Some tools are available to mode these - Kinetic Monte Carlo simulations (SSA and variants), Moment approximation methods, Finite State Projection. We will see how modeling these reactions can tell us more about the underlying processes of gene regulation.