Influence of lipid membranes rigidity on properties of supporting polymer [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 577.2 Specific factors affecting ecology
• Thông tin xuất bản: Los Alamos, N.M. : Oak Ridge, Tenn. : Los Alamos National Laboratory ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2012
• Mô tả vật lý: Medium: ED : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 262251
• Chủ đề: 1. 59 basic biological sciences; 2. 60 applied life sciences; 3. Elasticity; 4. Et al; 5. Flexibility; 6. Hydration; 7. Immobilized cells; 8. In vivo; 9. Lipids; 10. Matrices; 11. Membranes

Tóm tắt

 The motivation of this study is: (1) Controllable release of cultured cell sheets - (a) NIPAAm is non-toxic and collapsed at physiological Temp, (b) good platform for cell adherence and growth, (c) below polymer transition temp, cultured sheets are released, (d) hydration of matrix possible cause of cell attachment/detachment, (e) need for understanding hydration of underlying support
  (2) Matrix elasticity plays an important role in cell lineage specification - (a) matrices of known stiffness are utilized as supports to understand physical effect of in-vivo tissue microenvironment for therapeutic uses of stem cells, (b) it is believed that stem cells 'sense' the elasticity and transduce the information into morphological changes, (c) Imperative to consider the changes induced in matrix as a result of immobilized cells.