Linking Advanced Visualization and MATLAB for the Analysis of 3D Gene Expression Data [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 577.8 Synecology and population biology
• Thông tin xuất bản: Berkeley, Calif. : Oak Ridge, Tenn. : Lawrence Berkeley National Laboratory ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2011
• Mô tả vật lý: Size: 18 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 262365
• Chủ đề: 1. 59 basic biological sciences; 2. 60 applied life sciences; 3. 97 mathematical methods and computing; 4. Algorithms; 5. Data analysis; 6. Drosophila; 7. Embryos; 8. Et al; 9. Genes; 10. Genetics; 11. Medicine

Tóm tắt

Three-dimensional gene expression PointCloud data generated by the Berkeley Drosophila Transcription Network Project (BDTNP) provides quantitative information about the spatial and temporal expression of genes in early Drosophila embryos at cellular resolution. The BDTNP team visualizes and analyzes Point-Cloud data using the software application PointCloudXplore (PCX). To maximize the impact of novel, complex data sets, such as PointClouds, the data needs to be accessible to biologists and comprehensible to developers of analysis functions. We address this challenge by linking PCX and Matlab via a dedicated interface, thereby providing biologists seamless access to advanced data analysis functions and giving bioinformatics researchers the opportunity to integrate their analysis directly into the visualization application. To demonstrate the usefulness of this approach, we computationally model parts of the expression pattern of the gene even skipped using a genetic algorithm implemented in Matlab and integrated into PCX via our Matlab interface.