Gene by Disease Interaction on Orbitofrontal Gray Matter in Cocaine Addiction [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 574.87 [Unassigned]
• Thông tin xuất bản: Upton, N.Y. : Oak Ridge, Tenn. : Brookhaven National Laboratory ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2010
• Mô tả vật lý: Medium: ED : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 262380
• Chủ đề: 1. 59 basic biological sciences; 2. 60 applied life sciences; 3. Brain; 4. Cocaine; 5. Diseases; 6. Dopamine; 7. Et al; 8. Genes; 9. Genetic variability; 10. Genotype; 11. Lifetime

Tóm tắt

Chronic cocaine use has been associated with structural deficits in brain regions having dopamine receptive neurons. However, the concomitant use of other drugs and common genetic variability in monoamine regulation present additional structural variability. We therefore examined variations in gray matter volume (GMV) as a function of lifetime drug use and the monoamine oxidase A (MAOA) genotype in cocaine use disorders (CUD) and healthy controls.