Coordination of Endoplasmic Reticulum (ER) Signaling During Maize Seed Development [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 630.7 Education, research, related topics
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2010
• Mô tả vật lý: Size: 75 kb : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 262389
• Chủ đề: 1. 09 biomass fuels; 2. 59 basic biological sciences; 3. 60 applied life sciences; 4. Capacity; 5. Carbon; 6. Communications; 7. Deposition; 8. Endoplasmic reticulum; 9. Enzymes; 10. Et al; 11. Functionals

Tóm tắt

Seed storage reserves represent one of the most important sources of renewable fixed carbon and nitrogen found in nature. Seeds are well-adapted for diverting metabolic resources to synthesize storage proteins as well as enzymes and structural proteins needed for their transport and packaging into membrane bound storage protein bodies. Our underlying hypothesis is that the endoplasmic reticulum (ER) stress response provides the critical cellular control of metabolic flux required for optimal accumulation of storage reserves in seeds. This highly conserved response is a cellular mechanism to monitor the protein folding environment of the ER and restore homeostasis in the presence of unfolded or misfolded proteins. In seeds, deposition of storage proteins in protein bodies is a highly specialized process that takes place even in the presence of mutant proteins that no longer fold and package properly. The capacity of the ER to deposit these aberrant proteins in protein bodies during a period that extends several weeks provides an excellent model for deconvoluting the ER stress response of plants. We have focused in this project on the means by which the ER senses and responds to functional perturbations and the underlying intracellular communication that occurs among biosynthetic, trafficking and degradative pathways for proteins during seed development.