Advances and prospects in metabolic engineering of <i>Zymomonas mobilis</i> [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 541.3 Miscellaneous topics in physical chemistry
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2018
• Mô tả vật lý: Size: p. 57-73 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 263014
• Chủ đề: 1. 09 biomass fuels; 2. Biochemical production; 3. Biorefinery; 4. Industrial chassis; 5. Zymomonas mobilis

Tóm tắt

 Biorefinery of biomass-based biofuels and biochemicals by microorganisms is a competitive alternative of traditional petroleum refineries. <
 i>
 Zymomonas mobilis<
 /i>
  is a natural ethanologen with many desirable characteristics, which makes it an ideal industrial microbial biocatalyst for commercial production of desirable bioproducts through metabolic engineering. In this paper, we summarize the metabolic engineering progress achieved in <
 i>
 Z. mobilis<
 /i>
  to expand its substrate and product ranges as well as to enhance its robustness against stressful conditions such as inhibitory compounds within the lignocellulosic hydrolysates and slurries. We also discuss a few metabolic engineering strategies that can be applied in <
 i>
 Z. mobilis<
 /i>
  to further develop it as a robust workhorse for economic lignocellulosic bioproducts. In addition, we briefly review the progress of metabolic engineering in <
 i>
 Z. mobilis<
 /i>
  related to the classical synthetic biology cycle of ?Design-Build-Test-Learn?, as well as the progress and potential to develop <
 i>
 Z. mobilis<
 /i>
  as a model chassis for biorefinery practices in the synthetic biology era.