The ethanol pathway from Thermoanaerobacterium saccharolyticum improves ethanol production in Clostridium thermocellum [electronic resource]

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Ngôn ngữ: eng

Ký hiệu phân loại: 662.8 Other fuels

Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2017

Mô tả vật lý: Size: p. 175-184 : , digital, PDF file.

Bộ sưu tập: Metadata

ID: 263216

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Clostridium thermocellum
ferments cellulose, is a promising candidate for ethanol production from cellulosic biomass, and has been the focus of studies aimed at improving ethanol yield. 
Thermoanaerobacterium saccharolyticum
ferments hemicellulose, but not cellulose, and has been engineered to produce ethanol at high yield and titer. Recent research has led to the identification of four genes in 
T. saccharolyticum
involved in ethanol production: 
adhE
, 
nfnA
, 
nfnB
and 
adhA
. We introduced these genes into 
C. thermocellum
and observed significant improvements to ethanol yield, titer, and productivity. The four genes alone, however, were insufficient to achieve in 
C. thermocellum
the ethanol yields and titers observed in engineered 
T. saccharolyticum
strains, even when combined with gene deletions targeting hydrogen production. Here, this suggests that other parts of 
T. saccharolyticum
metabolism may also be necessary to reproduce the high ethanol yield and titer phenotype in 
C. thermocellum
.

1. 09 biomass fuels
2. 59 basic biological sciences
3. 60 applied life sciences

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The ethanol pathway from <i>Thermoanaerobacterium saccharolyticum</i> improves ethanol production in <i>Clostridium thermocellum</i> [electronic resource]