Optimization is a crucial step in the analysis of experimental results. Deterministic methods only converge on local optimums and require exponentially more time as dimensionality increases. Stochastic algorithms are capable of efficiently searching the domain space, however convergence is not guaranteed. This article demonstrates the novelty of hybrid genetic algorithm which combines both stochastic and deterministic routine for improved optimization results. A new hybrid genetic algorithm developed is applied to the Ackley benchmark function as well as case studies in foods, biofuels, and biotechnology processes. For each case study the hybrid genetic algorithm found a better optimum candidate than reported by the sources. In the case of food processing the hybrid genetic predicted 5% higher anthocyanin yield. Optimization of bio-oil production using HGA resulted in a 4.73 % higher yield. In enzyme production process HGA predicted 2.18 IU/gds of higher xylanase yield. In conclusion, hybridization of genetic algorithm with a deterministic algorithm resulted in maximum optimum compared to the statistical methods.