Consultancy on Large-Scale Submerged Aerobic Cultivation Process Design - Final Technical Report [electronic resource] : February 1, 2016 -- June 30, 2016

• Ngôn ngữ: eng
• Ký hiệu phân loại: 621.48 Nuclear engineering
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Energy Efficiency and Renewable Energy ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2017
• Mô tả vật lý: Size: 27 p. : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 264480
• Chủ đề: 1. 09 biomass fuels; 2. 59 basic biological sciences; 3. Bubble column; 4. Heat transfer; 5. Oxygen transfer

Tóm tắt

 NREL is developing an advanced aerobic bubble column model using Aspen Custom Modeler (ACM). The objective of this work is to integrate the new fermentor model with existing techno-economic models in Aspen Plus and Excel to establish a new methodology for guiding process design. To assist this effort, NREL has contracted Genomatica to critique and make recommendations for improving NREL's bioreactor model and large scale aerobic bioreactor design for biologically producing lipids at commercial scale. Genomatica has highlighted a few areas for improving the functionality and effectiveness of the model. Genomatica recommends using a compartment model approach with an integrated black-box kinetic model of the production microbe. We also suggest including calculations for stirred tank reactors to extend the models functionality and adaptability for future process designs. Genomatica also suggests making several modifications to NREL's large-scale lipid production process design. The recommended process modifications are based on Genomatica's internal techno-economic assessment experience and are focused primarily on minimizing capital and operating costs. These recommendations include selecting/engineering a thermotolerant yeast strain with lipid excretion
  using bubble column fermentors
  increasing the size of production fermentors
  reducing the number of vessels
  employing semi-continuous operation
  and recycling cell mass.