This paper presents real-world driving energy and fuel consumption results for the second-generation Chevrolet Volt plug-in hybrid electric vehicle (PHEV). A drive cycle, local to Michigan Technological University, was designed to mimic urban and highway driving test cycles in terms of distance, transients and average velocity, but with significant elevation changes to establish an energy intensive real-world driving cycle for assessing potential energy savings for connected and automated vehicle (CAV) control. The investigation began by establishing baseline and repeatability of energy consumption at various battery states of charge. It was determined that drive cycle energy consumption under a randomized set of boundary conditions varied within 3.6% of mean energy consumption regardless of initial battery state of charge. After completing 30 baseline drive cycles, a design for six sigma (DFSS) L18 array was designed to look at sensitivity of a range of parameters to energy consumption as related to connected and automated vehicles to target highest return on engineering development effort. The parameters explored in the DFSS array that showed the most sensitivity, in order of importance, were battery state of charge, vehicle mass, propulsion system thermal conditioning, HVAC setting and driver behavior. Each of these areas are explored for energy savings and discussed briefly in the context of CAV control opportunity for energy savings potential.