Challenges to deployment of connected and automated vehicle (CAV) technologies extend beyond the vehicle and systems engineering challenges, and arise from a set of technological, economic, demographic, and regulatory issues. Informed observers develop intuition about these challenges, but without analytic tools their understanding may be limited as a basis for considering possible actions. We moved beyond the limitations of such intuition to an integrated systems analysis capability to explore CAVs deployment potential. We analyzed the potential for large-scale adoption of CAVs and barriers to such adoption, using quantitative data and understandings of system relationships among stakeholders across the breadth of technological, economic, demographic, and regulatory issues.