Development of a phosphoaminopyrazine-loaded cellulose nanoparticle drug delivery system for targeted treatment of triple-negative breast cancer.

• Tác giả: Rabi Behrooz, Khodayar Gholivand, Fahimeh Mohammadpanah, Mahsa Pooyan, Roohollah Roohzadeh
• Ngôn ngữ: eng
• Ký hiệu phân loại: 338.9 Economic development and growth
• Thông tin xuất bản: Netherlands : International journal of biological macromolecules , 2025
• Bộ sưu tập: NCBI
• ID: 269104

Tóm tắt

 This study explores the development of a sustainable drug delivery system using cellulose nanoparticles (CNPs) derived from potato pulp for the controlled release of phosphoaminopyrazine (PAP), a promising anticancer agent. CNPs were synthesized via nanoprecipitation, and PAP was loaded through in-situ nanoprecipitation, achieving a high loading efficiency of 79.2 %. Characterization of CNPs and PAP-loaded CNPs (PAP@CNP) using Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and thermogravimetric analysis (TGA) confirmed the structural integrity, spherical morphology (45.33 nm for CNPs, 54.6 nm for PAP@CNP), and enhanced thermal stability of PAP@CNP. In vitro, drug release studies demonstrated sustained release over 48 h, with pH-sensitive kinetics favoring the acidic tumor microenvironment. Cytotoxicity assays revealed superior efficacy of PAP@CNP against triple-negative breast cancer cells (MDA-MB-231
  IC