PARP Inhibitors Differentially Regulate Immune Responses in Distinct Genetic Backgrounds of High-Grade Serous Tubo-Ovarian Carcinoma.

• Tác giả: Luiza Doro Pereira, Petar Jelinic, Alireza Khodadai-Jamayran, Douglas A Levine, Selim Misirlioglu, Monica Wielgos-Bonvallet
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Cancer research communications , 2025
• Bộ sưu tập: NCBI
• ID: 269540

Tóm tắt

This work highlights how different PARPis, especially talazoparib, modulate immune-related gene expression in ovarian cancer cells, independent of the cGAS-STING pathway. These findings may improve our understanding of how different PARPis affect the immune system in various genetic backgrounds.