Applications and emerging challenges of single-cell RNA sequencing technology in tumor drug discovery.

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Tác giả: Jianjun Tan, Yueying Yang, Lu Zhang

Ngôn ngữ: eng

Ký hiệu phân loại: 948.9701 Denmark and Finland

Thông tin xuất bản: England : Drug discovery today , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 284413

Current therapeutic drugs are inadequate for curing tumors, highlighting the need for novel tumor drugs. The advancement of single-cell RNA sequencing (scRNA-seq) technology offers new opportunities for tumor drug discovery. This technology allows us to explore tumor heterogeneity and developmental mechanisms at the single-cell level. In this review, we outline the application of scRNA-seq in tumor drug discovery stages, including elucidating tumor mechanisms, identifying targets, screening drugs, and understanding drug action and resistance. We also discuss the challenges and future prospects of using scRNA-seq in drug development, providing a scientific foundation for advancing tumor therapies.
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