Designed mosaic nanoparticles enhance cross-reactive immune responses in mice.

• Tác giả: Yusuf M Adia, Pamela J Bjorkman, Luis F Caldera, Arup K Chakraborty, Alexander A Cohen, Priyanthi N P Gnanapragasam, Jennifer R Keeffe, Annie V Rorick, Eric Wang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 620.004 Design, testing, measurement, quality, maintenance, repair
• Thông tin xuất bản: United States : Cell , 2025
• Bộ sưu tập: NCBI
• ID: 284501

Tóm tắt

Nanoparticle vaccines displaying combinations of SARS-like betacoronavirus (sarbecovirus) receptor-binding domains (RBDs) could protect against SARS-CoV-2 variants and spillover of zoonotic sarbecoviruses into humans. Using a computational approach, we designed variants of SARS-CoV-2 RBDs and selected 7 natural sarbecovirus RBDs, each predicted to fold properly and abrogate antibody responses to variable epitopes. RBDs were attached to 60-mer nanoparticles to make immunogens displaying two (mosaic-2