TET2-loss enhances immediate and time-resolved interferon-γ signaling responses across myeloid differentiation.

• Tác giả: Yunli E Chu, Kirsten M Dickerson, Rebecca Dubin, P Brent Ferrell, Alana M Franceski, Matthew T Jenkins, Stanley C Lee, Rui Lu, Chad R Potts, Robert S Welner
• Ngôn ngữ: eng
• Ký hiệu phân loại: 781.22 *Time
• Thông tin xuất bản: Netherlands : Experimental hematology , 2025
• Bộ sưu tập: NCBI
• ID: 284509

Tóm tắt

Signaling responses to cytokines are disrupted in clonal hematopoiesis and myeloid malignancies. To better identify specific signaling response alterations in the presence or absence of TET2, we developed a 36-parameter cytometry by time-of-flight (CyTOF) panel of both surface marker and phosphoprotein antigens in murine bone marrow (BM). We show diverse, cell-type specific inflammatory cytokine responses in healthy hematopoietic cells. We next investigated changes associated with BM cells from Tet2