rs762855 single nucleotide polymorphism modulates the risk for diffuse-type gastric cancer in females: a genome-wide association study in the Korean population.

• Tác giả: Seung Joo Kang, Joo Sung Kim, Nayoung Kim, Dong Ho Lee, Sejoon Lee, Jung Hun Ohn, Ji Hyun Park, Kyungtaek Park, Cheol Min Shin, Chin-Hee Song, Sungho Won, Ga-Eun Yie
• Ngôn ngữ: eng
• Thông tin xuất bản: Japan : Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association , 2025
• Bộ sưu tập: NCBI
• ID: 284560

Tóm tắt

 BACKGROUND: Intestinal-type gastric cancer (IGC) and diffuse-type gastric cancer (DGC) exhibit different prevalence rates between sexes. While environmental factors like Helicobacter pylori infection and alcohol consumption contribute to these differences, they do not fully account for them, suggesting a role for host genetic factors. METHODS: We conducted a meta-analysis to explore associations between single nucleotide polymorphisms (SNPs) and the risk of IGC or DGC. The analysis included the SNUBH cohort (998 participants: 159 DGCs, 303 IGCs, 4,962,361 variants) and the GC_HC cohort (6,233 participants: 389 DGCs, 405 IGCs, 4,541,617 variants). Significant variants were validated in the SNUBH2_AA cohort (5,511 participants: 40 DGCs, 49 IGCs, 3,668,632 variants). RESULTS: The meta-analysis identified that rs762855 (chr4:3,074,795
  hg19) is significantly associated with DGC risk in females (OR [95% CI]: 1.758 [1.438-2.150], P = 3.91 × 10 CONCLUSION: The rs762855 SNP, MSANTD1, and serum NAP levels are associated with DGC risk in Korean females.