Exercise-mediated epigenetic modifications in cardiovascular diseases.

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Tác giả: Shiliang Chen, Xinyu Hou, Qifeng Li, Yong Sun, Shiyu Wang, Xingyi Wang, Jian Wu, Xinyu Yang, Yanqi Zhang, Xianghui Zheng, Yang Zheng

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : Epigenomics , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 28582

Cardiovascular diseases (CVDs) represent a prominent contributor to global morbidity and mortality rates, with projections indicating a rise in this burden due to population aging. While extensive research has underscored the efficacy of exercise in mitigating the risk of CVDs, the precise mechanisms, particularly within the realm of epigenetics, remain nascent. This article delves into cutting-edge research concerning exercise-induced epigenetic alterations and their impact on CVDs. Initially, we examine the cardiac implications stemming from exercise-induced epigenetic influences across varying intensities. Subsequently, our focus shifts toward delineating the mechanisms governing exercise-induced DNA methylation, lactylation modifications, and N6-methyladenosine (m6A) RNA modifications, alongside addressing associated challenges and outlining prospective research directions. These findings suggest that exercise-mediated epigenetic modifications offer promising therapeutic potential for the prevention and comorbidity management of CVDs. However, the heterogeneity and tissue specificity of these effects necessitate more targeted research to unlock their full therapeutic potential.
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