Biểu hiện da và móng trên bệnh nhân ung thư vú được điều trị Trastuzumab

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Tác giả: Văn Trở Châu, Minh Vinh Ngô, Trọng Hào Nguyễn, Trọng Hiến Nguyễn, Việt Thanh Phúc Nguyễn, Hoàng Anh Thư Trương

Ngôn ngữ: vie

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Thông tin xuất bản: Tạp chí Y Dược học Phạm Ngọc Thạch, 2024

Mô tả vật lý: tr.69

Bộ sưu tập: Metadata

ID: 286312

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Đặt vấn đề: Tại Việt Nam, Trastuzumab được đưa vào sử dụng từ năm 2006, chỉ định cho bệnh nhân ung thư vú có Her-2/neu dương tính ở giai đoạn sớm cũng như tái phát di căn. Tác dụng phụ trên da và móng của Trastuzumab bao gồm những triệu chứng rối loạn về da: nổi ban ở mặt và thân người, tróc da và mỏng da bàn tay và bàn chân, ngứa, khô da
những triệu chứng rối loạn về móng: mềm móng, mỏng móng, mất móng, viêm quanh móng và mất màu móng. Đối tượng - Phương pháp: Nghiên cứu cắt ngang mô tả trên 277 bệnh nhân ung thư vú điều trị Trastuzumab từ tháng 06/2023 đến tháng 09/2023 tại Khoa Nội 4 - Bệnh viện Ung Bướu Thành phố Hồ Chí Minh. Kết quả: Tác giả tìm thấy mối liên quan có giá trị thống kê ở các bệnh nhân sử dụng phác đồ điều trị ung thư chỉ có Trastuzumab và các triệu chứng trên da và/ hoặc móng: 44,77% bệnh nhân có triệu chứng trên da, 31,05% bệnh nhân có triệu chứng trên móng, 17,69% bệnh nhân có triệu chứng trên cả da và móng. Mụn-phát ban mụn là triệu chứng da thường gặp nhất (20,22%), móng đổi màu là thay đổi móng thường gặp nhất (11,55%). Kết luận: Việc nhận biết các tác dụng phụ trên da và móng giúp điều trị sớm, phòng ngừa các biến chứng nặng và góp phần chăm sóc toàn diện cho bệnh nhân ung thư vú đang điều trị bằng phác đồ có Trastuzumab.Abstract Background: In Vietnam, Trastuzumab has been in use since 2006 and is prescribed for breast cancer patients who test positive for Her-2/neu, both in the early stages and during metastatic recurrence. The side effects of Trastuzumab include skin-related symptoms such as facial and body rashes, skin peeling, thinning, itching, and dryness on hands and feet
nail-related symptoms like softening, thinning, loss, paronychia, and discoloration. Subject - Method: Descriptive cross-sectional study on 277 breast cancer patients treated with Trastuzumab from June 2023 to September 2023 at Department of Internal Medicine 4 - Ho Chi Minh City Oncology Hospital. Results: There is a statistically significant association in patients receiving trastuzumab-only cancer regimens and skin and/or nail symptoms: 44,77% of patients have skin symptoms, 31,05% of patients have symptoms on the nails, 17,69% of patients have symptoms on both skin and nails. Acne was the most common skin symptoms (20.22%), nail discoloration was the most common nail change (11.55%). Conclusion: Recognizing side effects on the skin and nails helps to provide early treatment, prevent severe complications and contribute to comprehensive care for breast cancer patients undergoing treatment with the regimen containing Trastuzumab. DOI: 10.59715/pntjmp.3.4.9

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