NGHIÊN CỨU BÀO CHẾ CỐM CHỨA CHẤT CHIẾT TỪ CHÈ XANH VÀ NGHỆ VÀNG

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Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Thái Nguyên, 2020

Mô tả vật lý: tr.31-37

Bộ sưu tập: Báo, Tạp chí

ID: 292544

Thêm vào giỏ Liên kết toàn văn

Nghiên cứu được tiến hành nhằm xây dựng công thức bào chế của cốm chứa chất chiết từ nghệ vàng và chè xanh. Chè xanh được chiết xuất bằng phương pháp ngâm nóng, dung môi nước acid pH 3,0. Nghệ vàng được chiết xuất bằng phương pháp ngâm sử dụng bình ngấm kiệt, dung môi aceton 70%. Tỷ lệ dược liệu - dung môi là 1 - 10. Thời gian chiết 4 giờ, chiết 2 lần. Sau khi loại tạp và sấy khô, nghiền sản phẩm thành bột chè xanh (hàm lượng polyphenol khoảng 41%) và bột nghệ vàng (hàm lượng curcumin khoảng 92%). Bột nghệ vàng được bào chế hệ phân tán rắn bằng phương pháp đun chảy. Cốm được bào chế bằng phương pháp xát hạt qua rây với tỷ lệ chè xanh - hệ phân tán rắn nghệ vàng - glucose là 1- 3,75 - 8
sử dụng tá dược dính ethanol 96% và tá dược trơn là magnesi stearat và talc. Sản phẩm thu được có màu vàng nâu, khô tơi, vị ngọt thanh, độ rã <
5 phút, hàm ẩm dưới 5% và độ đồng đều khối lượng nằm trong khoảng ± 7,5% so khối lượng trung bình gói.The study was conducted to formulate of granulated medicine containing extracts of curcuma longa L and green tea. Green tea is extracted by hot soaking method, with acidic water solution having pH 3.0. Curcuma longa L is extracted by immersion method using an infused flask, with the solvent being 70% acetone. The ratio of medicinal herbs to the solvent is 1:10. The extraction time is 4 hours with twice extraction. After removing impurities and drying process, the product is ground into powder consisting of green tea (about 41% polyphenol content) and curcuma longa L (about 92% curcumin content). A solid dispersion system of curcuma longa L extract is prepared by melting method. Granulated medicine is prepared by wet granulation method with the ratio of green tea to solid dispersion system curcuma longa to glucose being 1:3.75:8
binder and lubricant excipients used are 96% ethanol and magnesium stearate and talc, respectively. The product obtained is yellow brown, dry, sweet, having less than five-minute decomposition, <
5% moisture content and equitable mass ranging within ± 7.5% of the average mass of the packages.

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