LỰA CHỌN CÔNG THỨC TỐI ƯU CHO NANO NHŨ TƯƠNG CHỨA CURCUMIN

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Ngôn ngữ: vie

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Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Thái Nguyên, 2020

Mô tả vật lý: tr.38-42

Bộ sưu tập: Báo, Tạp chí

ID: 292551

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Curcumin is a natural active composition used for effection and cancer, however, it has low bioavailability because of its dissolution in water in oral route, with its advantages that are easier to prepare, more stable, and small size of droplet, the nanoemulsion easily go through intestinal walls into blood and the bioavailability of curcumin in oral route could be improved. Base on recent results of the effective factors on droplet sizes of nanoemulsion, MODDE and Inform were used to optimize the formulation of curcumin nanoemulsion. Nanoemulsion comprising curcumin was prepared with an emulsion method with supporting high-speed homogenizer and ultrasound waves. The size of droplets and stability were evaluated by the micro crops method. The results showed that drops size of nanoemulsion was clearly affected by the amount of Tween 80 but not by amount of polyethylene glycol 400 that had almost effected on stability. So that the formulation of nanoemulsion containing curcumin was optimized and chosen.Curcumin là hoạt chất thiên nhiên có tác dụng chống viêm, ức chế sự phát triển của tế bào ung thư nhưng ít tan nên sinh khả dụng thấp khi uống. Với ưu điểm dễ bào chế, ổn định hơn và kích thước nhỏ, nano nhũ tương chứa curcumin có thể thấm qua niêm mạc tiêu hóa và tăng sinh khả dụng. Trên cơ sở kết quả đánh giá một số yếu tố ảnh hưởng tới kích thước tiểu phân và độ ổn định, nghiên cứu tiếp tục sử dụng phần mềm Modde và Inform nhằm mục tiêu lựa chọn công thức tối ưu cho nano nhũ tương chứa curcumin. Nano nhũ tương chứa curcumin được bào chế bằng phương pháp nhũ hóa với sự hỗ trợ của kỹ thuật siêu âm kết hợp đồng nhất hóa. Đánh giá độ ổn định và kích thước tiểu phân bằng phương pháp hiển vi. Kết quả cho thấy kích thước tiểu phân của nano nhũ tương bị thay đổi rõ rệt khi thay đổi lượng Tween 80, nhưng không ảnh hưởng bởi lượng polyethylen glycol 400, mà PEG 400 chỉ chủ yếu ảnh hưởng đến độ ổn định của nano nhũ tương. Từ đó, công thức nano nhũ tương chứa curcumin đã được tối ưu và lựa chọn.

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