Chemical Biology of Nucleic Acids [electronic resource] : Fundamentals and Clinical Applications

• Tác giả: Jan Barciszewski, Volker A Erdmann, Wojciech T Markiewicz
• ISBN-13: 978-3642544521
• Ký hiệu phân loại: 547.7 Macromolecules and related compounds
• Thông tin xuất bản: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2014.
• Mô tả vật lý: XI, 599 p. 231 illus., 84 illus. in color. , online resource.
• Bộ sưu tập: Tài liệu truy cập mở
• ID: 292808
• Chủ đề: 1. Biology-Research; 2. Biomaterials; 3. Medical genetics; 4. Medicine-Research; 5. Nucleic acids

Tóm tắt

 This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology
  the establishment of the genetic code
  isomerization of RNA
  damage of nucleobases in RNA
  the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport
  molecular crowding by the use of ionic liquids
  new technologies enabling the modification of gene expression via editing of therapeutic genes
  the use of riboswitches
  the modification of mRNA cap regions
  new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids. This volume discusses how chemistry can add new frontiers to the field of nucleic acids in molecular medicine, biotechnology and nanotechnology and is not only an invaluable source of information to chemists, biochemists and life scientists but will also stimulate future research.