Biomolecular Interfaces [electronic resource] : Interactions, Functions and Drug Design

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Tác giả: Fernández Stigliano Ariel.

Ngôn ngữ:

ISBN-13: 978-3319168500

Ký hiệu phân loại: 572.6 Proteins

Thông tin xuất bản: Cham : Springer International Publishing : Imprint: Springer, 2015.

Mô tả vật lý: XIX, 372 p. 145 illus., 86 illus. in color. , online resource.

Bộ sưu tập: Tài liệu truy cập mở

ID: 292926

The book focuses on the aqueous interface of biomolecules, a vital yet overlooked area of biophysical research. Most biological phenomena cannot be fully understood at the molecular level without considering interfacial behavior. The author presents conceptual advances in molecular biophysics that herald the advent of a new discipline, epistructural biology, centered on the interactions of water and biomolecular structures across the interface. The author introduces powerful theoretical and computational resources in order to address fundamental topics such as protein folding, the physico-chemical basis of enzyme catalysis and protein associations. On the basis of this information, a multi-disciplinary approach is used to engineer therapeutic drugs and to allow substantive advances in targeted molecular medicine. This book will be of interest to scientists, students and practitioners in the fields of chemistry, biophysics and biomedical engineering.
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