B Cell Receptor Signaling [electronic resource]

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Tác giả: Tomohiro Kurosaki, Jürgen Wienands

Ngôn ngữ:

ISBN-13: 978-3319261331

Ký hiệu phân loại: 571.96 +Immunity

Thông tin xuất bản: Cham : Springer International Publishing : Imprint: Springer, 2016.

Mô tả vật lý: X, 231 p. , online resource.

Bộ sưu tập: Tài liệu truy cập mở

ID: 293780

This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton's Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.
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