So sánh chất lượng vacxin đa giá vô hoạt bổ trợ keo phèn và bổ trợ nhũ dầu chế tạo phòng bệnh viêm phổi cho lợn

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Tác giả: Cảm Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học kỹ thuật Thú y, 2019

Mô tả vật lý: tr.40

Bộ sưu tập: Metadata

ID: 293988

Thêm vào giỏ Liên kết toàn văn

Bộ giống vi khuẩn (master seed) bao gồm: 3 chủng A. pleuropneumoniae, 2 chủng P. multocida và 1 chủng S. suis được Cục Thú y cho phép sử dụng để sản xuất và lưu hành vacxin viêm phổi đa giá vô hoạt bổ trợ keo phèn tại công ty Marphavet cũng đã được sử dụng để chế tạo vacxin viêm phổi đa giá vô hoạt có bổ trợ nhũ dầu phòng bệnh viêm phổi ở lợn.Cả 2 loại vacxin đã chế tạo (có chất bổ trợ keo phèn và nhũ dầu) đều đạt chất lượng: vô trùng 100%, an toàn 100% khi kiểm tra trên chuột và trên lợn. Hiệu lực phòng bệnh của cả 2 loại vacxin trên chuột bằng phương pháp miễn dịch thụ động đạt trên 80,0% khi công cường độc. Bằng phương pháp ELISA, đã xác định được cả 2 loại vacxin trên đều kích thích lợn sản sinh kháng thể kháng vi khuẩn A. pleuropneumoniae serotype 2 và 5 với hiệu giá cao sau 21 ngày tiêm vacxin ở lợn từ 4 tuần tuổi, hiệu giá kháng thể của vacxin nhũ dầu cao hơn hiệu giá kháng thể của vacxin keo phèn.In this research, the master seed bacteria strains, including three strains of A. pleuropneumoniae, two strains of P.multocida and one strain of S. suis were approved by Department of Animal Health to produce the aluminum hydroxide adjuvant, inactivated multivalent vaccine, they were also used to develop an inactivated multivalent vaccine with oil emulsion adjuvant to prevent pneumoniae in swine.Both vaccines (with aluminium hydroxide and oil emulsion adjuvant) were found to be good quality with 100% sterility and 100% safety, which was proved through the experimental tests on mice and pigs. Both vaccines passed the potency test with a protection rate of 80% on mice, using challenge method.Using ELISA technique, it was detected that both vaccines stimulated the pigs in producing antibodies to A. pleuropneumoniae serotypes 2 and 5 with high titers after 21 days of vaccination in pigs from four weeks of age. The antibody titer of oil emulsion adjuvant vaccine was higher than that of the aluminium hydroxide adjuvant vaccine.

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