To monitor the rapidly changing economic landscape due to Coronavirus 2019 (COVID-19), the National Institute of Statistics of Djibouti (INSD), with the technical assistance from the World Bank, conducted a second wave of the COVID phone survey from September 20 to October 18, 2020. The sample, consisting of 1,460 complete interviews, combined a panel of households interviewed during the first wave, to which a replacement sample was added to compensate for attrition. The response rate stands at 85 percent nationally and the results are representative of the country’s urban population except for the top wealth quintile (richest 20 percent). Since mid-May, when the lockdown ended, economic activities have been trending back to normal. In times of COVID-19, households contend with significant challenges regarding access to food, a key element of food insecurity. The survey uncovers that 40 percent of the households are worried about not having enough food due to a lack of economic resources. Despite the challenging health and economic context, many households remained optimistic about the future.