Cambodia is highly exposed and vulnerable to climate change, which has significant direct and indirect impacts on human health. Climate-related hazards - such as heavy rainfall, flooding, landslides, sea-level rises, extreme heat, droughts, wildfires, and storms - affect agricultural productivity significantly, with tremendous implications on food security and nutrition. They also lead to increased waterborne disease (WBD) outbreaks and the transmission of vector-borne diseases (VBDs) in Cambodia. Moreover, flooding, strong winds, and extreme heat cause damage to the health infrastructure, medical equipment, and supplies in the country. The increasing burden of climate-sensitive diseases, coupled with the impacts on the health infrastructure, is putting pressure on the already fragile health system in the country, thereby affecting adaptive capacity and increasing health inequalities in Cambodia. The objective of this Climate and Health Vulnerability Assessment (CHVA) is to assist decision-makers with planning effective adaptation measures to deal with climate-related health risks.