HOẠT TÍNH ỨC CHẾ α-GLUCOSIDASE CỦA BA LOÀI RONG LỤC THU TẠI VÙNG BIỂN KHÁNH HÒA

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả:

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Thái Nguyên, 2020

Mô tả vật lý: tr.305-312

Bộ sưu tập: Metadata

ID: 302223

Thêm vào giỏ Liên kết toàn văn

Một trong những cách hiệu quả để kiểm soát bệnh đái tháo đường type 2 là ức chế hoạt động của α-glucosidase. Nghiên cứu này đánh giá hoạt tính ức chế α-glucosidase của 3 loài rong lục (Halimeda macroloba, Ulva reticulata và Ulva lactuca) thu mẫu tại vùng biển Khánh Hòa và kết quả nghiên cứu cho thấy, hoạt tính ức chế α-glucosidase (giá trị IC50) của 3 loài H. macroloba, U. reticulata và U. lactuca lần lượt là 3,98
4,76 và 5,21 mg/ml. Ảnh hưởng của thời gian chiết và nhiệt độ chiết đến hoạt tính ức chế α-glucosidase của loài rong lục H. macroloba được nghiên cứu thích hợp tương ứng ở 60 phút chiết và 60°C. Trong các phân đoạn dung môi chiết, phân đoạn ethyl acetate có hoạt tính ức chế α-glucosidase cao nhất (giá trị IC50 là 2,45 mg/ml), tiếp theo là n-hexane, butanol và nước với giá trị IC50 lần lượt là 2,79
4,11 và 4,91 mg/ml. Kết quả nghiên cứu định tính cho thấy phân đoạn ethyl acetate của loài rong lục H. macroloba có mặt của các nhóm chất phenolic, flavonoid và terpenoid.One of the effective therapeutic approaches in the management of type 2 diabetes is inhibition of α-glucosidase. This study investigated α-glucosidase inhibitory activity of three green seaweeds (Halimeda macroloba, Ulva reticulate and Ulva lactuca) and the results indicated that the inhibitory effect (IC50 values) of H. macroloba, U. reticulata and U. lactuca and were 3.98, 4.76 and 5.21 mg/ml, respectively. The suitable extraction time and extraction temperature for extracting high activity α-glucosidase inhibitors from green seaweed H. macroloba were found to be 60 min and 60 °C, respectively. Among the extract fractions, ethyl acetate showed the highest α-glucosidase inhibitory activity (IC50 value of 2.45 mg/ml), followed by n-hexane, butanol and water with IC50 values of 2.79, 4.11 and 4.91 mg/ml, respectively. Phytochemical screening showed phenolic, flavonoids and terpenoid were present in the ethyl acetate fraction of green seaweed H. macroloba.

1.

Tạo bộ sưu tập với mã QR