The objective of this Climate and Health Vulnerability Assessment (CHVA) is to assist decision-makers in Colombia with planning effective adaptation measures to deal with climate-related health risks. This assessment includes sub-national considerations for health-related climate action (see Annex A for the methodology). Sub-national considerations are given for Colombia's 32 departments (see Figure 1). It also incorporates data from a Climate and Health Economic Valuation conducted by the World Bank to estimate of the potential economic costs of health impacts arising from projected changes in temperature and precipitation (see Annex B for the methodology). The findings from this CHVA are organized under four sections. Section I characterizes the climatology in Colombia, highlighting observed and projected climate exposures relevant to health. Section II describes key climate-related risks to health, including nutrition and food security, vector-borne diseases (VDBs), water-borne diseases, increasing temperatures, air quality, and zoonotic diseases. Section III analyzes the adaptive capacity and readiness of Colombia's health system to prevent and manage climate-related health risks. Recommendations are discussed in Section IV.