Livestock systems globally are changing rapidly in response to a variety of drivers. Human population growth, rapid urbanization, and growing incomes will lead to substantial increases in the demand for livestock products in the coming decades. Meeting this increased demand may put substantial pressure on a wide range of natural resources such as land and water. Together with climate change and increasing climate variability, these drivers of change add up to a formidable set of development challenges for developed as well as developing countries. The paper discusses the linkages between the burgeoning demand for livestock products, the subsequent growth in livestock production, and the impacts that this may have on natural resources, as well as how these may both affect, and be affected by, climate change in the coming decades.