This study's aim was to assess the growing flood risk Sao Tome and Principe (STP) faces due to climate change. It achieved this by carrying out a nationwide risk assessment for riverine and coastal flooding. The study used recently completed high-resolution national flood hazard data for the present climate (2020) and two projected climates (in 2050 and 2080), based on the climate scenario Shared Socioeconomic Pathways (SSP)3-7.0, a medium to high reference scenario resulting from no additional climate policy under the SSP3 socioeconomic development narrative.This flood risk assessment examines the potential impacts and risks to people, buildings, healthcare facilities, the education sector, and tourism under both present and future climate conditions. It shows that flood risk is driven frequent flood events. There is a significant increase of flood risk under future climate conditions.