The Latin America and Caribbean (LAC) region has been in many ways successful in increasing agriculture production and competitiveness, as well as tackling nutrition. Mainstreaming nutrition considerations into agriculture operations can increase the availability of and access to nutritious food, which can improve the nutrition status of individuals. The challenge is how to bridge the gap that exists in region between being an agriculture powerhouse and yet having to tackle nutrition problems from the same households that produce the food. The new challenge of integrating nutrition and agriculture should be achievable with political leadership and inter-institutional coordination. This guidance note seeks to bridge some of the important knowledge gaps on how best to identify, design, implement, monitor, and evaluate agriculture and food security interventions. This note describes first the current situation in LAC with respect to agriculture and nutrition, then offers practical guidance to task team leaders (TTLs) regarding the available levers for positively impacting nutrition outcomes of agriculture projects, and presents a series of country notes and steps to be followed in designing nutrition sensitive interventions.