Nghiên cứu nồng độ kháng nguyên CA125 ở bệnh nhân ung thư bạch cầu.

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Tác giả: Trang Bui Kieu, Phuong Thao Tran Thi, Xuan Nguyen Thi, Tong Hoang Van

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ Việt Nam - B, 2020

Mô tả vật lý: tr.1

Bộ sưu tập: Metadata

ID: 309126

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Cancer Antigen 125 (CA125) has been used as a biomarker for early diagnosis of several cancers. This study aims to determine concentration of CA125 in Vietnamese patients with leukemia. The blood samples of 103 untreated patients diagnosed with different types of leukemia and 33 healthy individuals were included for this study. Level of CA125 in the blood was measured by ELISA. The results showed that patients with acute lymphocytic leukemia had an increased CA125 level compared to the healthy controls (p<
0.05). CA125 level was not significantly different among patients with chronic lymphocytic leukemia, acute myeloid leukemia, and healthy individuals (p>
0.05). Patients with chronic myeloid leukemia had a lower CA125 level than the healthy controls (p=0.05). The results indicated that CA125 might be a potential marker for early diagnosis of acute lymphoblastic leukemia.Kháng nguyên ung thư 125 (CA125) được biết đến và sử dụng với vai trò là một biomarker trong chẩn đoán một số bệnh ung thư. Nghiên cứu này được thực hiện nhằm mục đích đánh giá mức độ biểu hiện CA125 ở những bệnh nhân mắc ung thư bạch cầu tại Việt Nam. 103 bệnh nhân được chẩn đoán mắc ung thư bạch cầu chưa được điều trị và 48 người khỏe mạnh đã tham gia nghiên cứu. Nồng độ của protein CA125 trong máu được phát hiện và định lượng bằng phương pháp ELISA. Kết quả cho thấy, những bệnh nhân bạch cầu lympho cấp có nồng độ CA125 tăng cao và có sự khác biệt với những người khỏe mạnh (p<
0,05). Nồng độ CA125 không có sự khác biệt ở những bệnh nhân bạch cầu lympho mạn tính, bạch cầu tủy cấp so với những người khỏe mạnh (p>
0,05). Những bệnh nhân bạch cầu tủy mạn có nồng độ CA125 thấp hơn so với người khỏe mạnh (p=0,05). CA125 có thể là một marker tiềm năng đối với bệnh bạch cầu lympho cấp.

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