Đánh giá mối liên quan giữa hình thái phôi nang với bất thường nhiễm sắc thể.

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Tác giả: Dinh Tao Nguyen, Minh Ngan Hoang, Sang Trieu Tien, Nam Nguyen Trung

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ Việt Nam - B, 2020

Mô tả vật lý: tr.15

Bộ sưu tập: Metadata

ID: 309152

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Conducting research on the relationship between blastocyst’s morphology and chromosome abnormality by retrospective and cross-sectional description studies in 953 embryos on day 5 analysed for preimplantation genetic screening (PGS) at assisted reproductive technology center, 16A Ha Dong General Hospital from February 2018 to May 2019 exhibited that the rates of mosaic, numerical abnormality and structural abnormality were 56.68%, 36.65%, and 6.67%, respectively. The number of normal blastocyst accounted for the majority in good morphological embryo group (69.1%). The incidence of 1, 2 or 3 chromosome abnormalities per embryo increased gradually in the medium and bad morphology embryos group. A higher proportion of chromosome abnormality was found in association with low expansion degree, ICM C and TE C. The top quality morphology of day 5 embryo was found in association with the decreasing risk of chromosome abnormality (p<
0.001, OR=0.22, CI95%=0.16-0.29). In conclusion, there was a significant relationship between morphological blastocyst and chromosome abnormality. The low expansion degree, TE C, ICM C, and poor quality morphological blastocyst associated with an increase in the rate of chromosome abnormality.Nghiên cứu mối liên quan giữa hình thái phôi nang với bất thường nhiễm sắc thể (NST) được thực hiện theo phương pháp nghiên cứu hồi cứu, mô tả cắt ngang trên 953 phôi ngày 5 được làm sàng lọc NST tại Bệnh viện Đa khoa 16A Hà Đông từ tháng 2/2018 tới 5/2019 cho thấy, tỷ lệ bất thường NST rất lớn ở phôi nang (bất thường khảm chiếm 56,68%, bất thường số lượng NST là 36,65%, bất thường cấu trúc 6,67%). Số phôi bình thường chiếm đa số ở nhóm phôi phân loại hình thái tốt (69,1%). Tỷ lệ có 1, 2, 3 bất thường tăng dần ở nhóm phôi trung bình và xấu. Nguy cơ bất thường NST tăng lên khi độ giãn rộng (ĐGR) khoang phôi thấp và hình thái lá nuôi, hình thái nụ phôi (ICM) xấu. Với hình thái phôi ngày 5 xếp loại tốt, nguy cơ bất thường NST giảm (p<
0,001, OR=0,22, CI95%=0,16-0,29). Kết quả nghiên cứu cho thấy, có mối liên quan chặt chẽ giữa hình thái phôi nang với bất thường NST. ĐGR của phôi thấp, hình thái của lá nuôi, ICM và hình thái phôi nang xấu thì tỷ lệ bất thường NST tăng lên.

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