This playbook presents an end-to-end roadmap of elements and activities that underpin ecosystems capable of supporting safe and sustainable high-frequency drone operations The focus is on enabling operations using small to medium-size drones or un-crewed aircraft system (UAS) within health, urban land administration, and other sectors. Those are likely to provide significant socio-economic benefits in the near to medium term. The majority of these operations will likely take place within low-level airspace generally shared with helicopters, other UAS, and conventional aviation during take-off and landing. Further, such operations are intended to provide the most near-term opportunities to address deficiencies in current operations and supply chains and support development in line with the Sustainable Development Goals - including Goal 2 (enhancing food security), 3 (good health and wellbeing), 8 (economic growth and decent job possibilities), and 9 (resilient infrastructure and fostering innovation).