The principal purpose of this Global Program Review (GPR) is to learn lessons from the experience of the Global Fund and its interaction with the Bank in three areas: (a) the design and operation of large global partnership programs like the Global Fund that are financing country-level investments, (b) the engagement of the World Bank with these partnership programs, and (c) the evaluation of these programs. The Review has an intensive focus on the Bank's engagement with the Global Fund at the country level because of the potential for competition or collaboration between Global Fund-supported activities and the Bank's lending operations at the country level. Therefore, it also focuses on the design and operation of the Global Fund-supported activities at the country level. This review was initiated before the high-level independent review panel on fiduciary controls and oversight mechanisms of the Global Fund was commissioned in February 2011, and it was drafted before their final report, turning the page from emergency to sustainability, was issued on September 19, 2011. While the two studies are complementary and overlap to some extent, they were conducted independently of each other, for different audiences, and for different purposes.