ADAMTS13 attenuates renal fibrosis by suppressing thrombospondin 1 mediated TGF-β1/Smad3 activation.

• Tác giả: Yu Cui, Fang Dong, Jie Guo, Shan Jiang, En Yin Lai, Pengyun Li, Ruisheng Liu, Zufu Ma, Xingyu Qiu, Honghong Wang, Nan Xu, Liang Zhao, Suhan Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 634.62 *Dates
• Thông tin xuất bản: United States : Toxicology and applied pharmacology , 2025
• Bộ sưu tập: NCBI
• ID: 31567

Tóm tắt

Renal fibrosis is a common pathologic pathway for the progression of chronic kidney disease (CKD) to end-stage renal disease (ESRD). Its mechanisms are unclear and it lacks effective therapy. Thrombospondin 1 (TSP1) mediated transforming growth factor-β1 (TGF-β1) activation was confirmed to promote renal fibrosis. Recently, a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13 (ADAMTS13), was reported to inhibit Thrombospondin 1 (TSP1) mediated Ca