This study was conducted to evaluate the advantages of tourist attractions in the key region of An Giang province. The Synthetic Marking Scheme (SMS) and Analytic Hierarchy Process (AHP) were both utilized to evaluate 29 tourist destinations in the region within eight indicators, including attraction, infrastructure, management, sustainability, linkage ability, location, capacity, and tourist operation timetable. The result shows that among the 26 evaluated tourist attractions, there were 8 attractions at the group I (highest advantage), 4 at the group II (advantage), 8 at the group III (medium advantage) and 6 last tourist attractions in group IV (less advantage). In order to exploit its potentials effectively, the regional tourism department would need to continuously concentrate on enhancing the quality of services in terms of the high advantage-rated attractions, while diversifying the different types of tourism activities within the medium and less advantage-rated attractions.