This report summarizes the findings of an allocative efficiency analysis on the Kyrgyz Republic`s national HIV epidemic and response conducted in 2014-15. The report addresses core questions for resource allocation such 'How can HIV funding be optimally allocated to the combination of HIV response interventions that will yield the highest impact?' or 'What level of investment is required to achieve national targets, if we allocate resources optimally?'. The report describes epidemiological and HIV financing trends as well as identifies sub-populations, which are most affected by the epidemic. Based on this information, the optimized mix of interventions for minimizing new HIV infections and deaths is identified using mathematical modelling techniques. Required investments into programs for key populations and antiretroviral treatment are established and translated into policy recommendations. The Kyrgyz Republic's HIV epidemic is transitioning from an early concentrated epidemic among people who inject drugs (PWID) into an advanced concentrated HIV epidemic with continued transmission among PWID, but an increasing share of sexual transmission to female partners of PWID and among men who have sex with men (MSM). The Optima model projected that, with current spending, the estimated 1,000 annual new infections in 2014 will increase to 1,100, and estimated deaths from 400 in 2014 to 600 deaths per year on average, over 2015-20.