Lake Victoria, a vital resource for East African countries, faces threats from unsustainable land management, human waste, and industrial effluent, impacting its water quality, biodiversity, and navigability. Recognized as a regional economic zone by the East African Community, the Lake Victoria Basin (LVB) requires aC coordinated regional approach to address these challenges. The Lakewide Inclusive Sanitation (LWIS) Strategy offers a multilateral solution to the basin's sanitation issues, exacerbated by rapid urbanization and inadequate wastewater treatment. With 33 million people in the LVB lacking improved sanitation, the LWIS Strategy aims to improve water quality and human capital through comprehensive sanitation improvements, technical innovation, institutional reforms, and financial mobilization. This approach also engages the private sector in innovation, service delivery, and job creation, emphasizing the need for a strong, coordinated regional effort to enhance lake functions, provide safe sanitation, and strengthen community resilience against climate change and other crises.