Gender-based Violence (GBV) is the most egregious manifestation of gender inequality and an alarming global public health, human rights and development challenge. It is most often perpetrated against women and girls. This note reviews available data and evidence on GBV, outlines promising approaches, and presents strategic and operational recommendations. The following key messages serve as a call-to-action to policymakers, practitioners, researchers, and organizations seeking to eradicate GBV: • GBV prevention and response clear the path to reach development goals, including gender equality. • Institutionalizing GBV prevention and response across sectors, supported by adequate financing, can help prevent violence. Investments in technical expertise are essential. • Collaboration and coordination with international and national partners as well as the private sector are critical for inclusive, sustainable, and deeper engagements. Supporting national coordinating bodies can enhance an effective and coherent multi-sectoral approach.