The Mekong Delta (MKD) is Vietnam's most productive agricultural region, and its agroeconomy is well integrated into international markets. Nevertheless, there are increasing threats to the MKD's agricultural achievements, and other serious questions are emerging about the sustainability of many of the prevailing production systems. Sea level rise, caused by climate change, is increasingly threatening the viability of once protected cropping systems in the coastal areas. This study seeks to contribute to the planning effort for the MKD by addressing some analytical gaps, especially around the technical feasibility and socioeconomic characteristics of alternative agricultural production systems in the context of the evolving natural conditions in the region, and more specifically in the MKD's three subregions (that is, Upper, Middle, and Coastal). The primary purpose of the study is to fill in that gap by reviewing and assessing different livelihood models and land-use scenarios in the MKD using multi-criteria of technical feasibly, climate change, environmental adaptability, economic and financial, and social aspects to inform the ongoing agricultural transformation in the MKD.