The book constitutes the thoroughly refereed post-workshop proceedings of the First Workshop on Bio-Inspired Design of Networks, BIOWIRE 2007, held in Cambridge, UK, in April 2007. The 35 revised full papers presented were carefully reviewed and selected from many high quality submissions. All recent developments in the field of bio-inspired design of networks are addressed, with particular regard to wireless networks and the self-organizing properties of biological networks. The papers are organized in topical sections on biological networks, network epidemics, complex networks, bio-inspired network mode, network protocol in wireless communication, data management, distributed computing, and security.