Khảo sát tác động giảm đau và an thần của cao chiết ngó sen (Nelumbo nucifera Gaertn. Nelumbonaceae) trên chuột nhắt trắng

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Tác giả: Thị Ngọc Ánh Mai, Gia Mẫn Thái, Thị Thu Hà Võ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Nguyễn Tất Thành, 2020

Mô tả vật lý: tr.59

Bộ sưu tập: Metadata

ID: 324778

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In Viet Nam, Nelumbo nucifera Gaertn. Nelumbonaceae is a popular aquatic plant. All parts of Nelumbo nucifera Gaertn. have been used in traditional medicine. The objective of this study was to evaluate acute toxicity, analgesic and anxiolytic effects of extract of Nelumbo nucifera Gaertn. The percolation method with 70 % ethanol was conducted to obtain the extract. Acute toxicity test was performed on Swiss albino mice at the maximum possible oral dose. Mice were observed up to 14 days post-treatment. Central analgesic effect was evaluated with tail immersion model, peripheral analgesic effect was evaluated with writhing test using 1 % acetic acid in mice. The anxiolytic effect was investigated based on Rotarod performance. The results revealed that the maximum possible infralethal dose of the extract at 61,6 g/kg mouse body weight. The rhizome of Nelumbo nucifera Gaertn. extract at doses of 1,5 g/kg and 3 g/kg mouse body weight show anxiolytic and peripheral analgesic effects but no central analgesic effects. The results of this study would be useful for further study on natural medicine used in supporting the treatment of conditions as stress, insomnia.Sen (Nelumbo nucifera Gaertn.) thuộc dạng cây thủy sinh nổi trên mặt nước. Ở Việt Nam, các bộ phận của cây Sen đều có thể sử dụng trong y học cổ truyền. Mục tiêu của nghiên cứu là xác định độc tính cấp và tác dụng giảm đau, an thần của cao chiết ngó sen. Dùng phương pháp ngấm kiệt nguyên liệu sơ chế với cồn 70 độ để thu được cao đặc. Thử nghiệm độc tính cấp sử dụng liều tối đa trên chuột được theo dõi trong 14 ngày. Khảo sát tác động giảm đau trung ương trên mô hình nhúng đuôi chuột, tác động giảm đau ngoại biên trên mô hình gây đau quặn bụng bằng acid acetic. Tác động an thần được khảo sát bằng phương pháp Rotarod. Kết quả định tính xác định được liều dung nạp tối đa ( ) đối với cao chiết ngó sen là 61,6 g/kg. Cao chiết ngó sen liều 1,5 g/kg và 3 g/kg thể hiện tác động an thần và giảm đau ngoại biên nhưng không có tác động giảm đau trung ương trên mô hình thực nghiệm. Kết quả nghiên cứu có thể được định hướng cho các nghiên cứu sâu hơn về các dạng chế phẩm từ tự nhiên trong hỗ trợ điều trị các bệnh căng thẳng, mất ngủ

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