Protecting water sources is an essential issue for ensuring the supply of clean water to people. Many human activities are affecting the water sources in households. This study conducted face-to-face interviews on 169 households in order to analyze the current status of domestic water supply and environmental sanitation practices in peri-urban areas of Pleiku city. The Focus Discussion Group method was also used to assess stakeholder participation in implementing measures in improving water sources and sanitation. The results showed that most of the households are using groundwater for daily domestic purposes because the municipal water supply system has not been installed in the studied areas. In addition, most households are satisfied with the quality of existing groundwater. However, the lack of water and some problems of water quality sometimes occur in the dry season. In order to protect groundwater, waste, and wastewater from livestock and agricultural activities should be controlled.