Nhận xét kết quả hóa trị bổ trợ phác đồ 4AC-4T kết hợp Anastrozole cho bệnh nhân ung thư vú ER dương tính/Her2 âm tính giai đoạn II-III

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Tác giả: Văn Thịnh Thân, Lê Huy Trịnh

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ Việt Nam - B, 2022

Mô tả vật lý: tr.10

Bộ sưu tập: Báo, Tạp chí

ID: 327719

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Chemotherapy regimen 4AC-4T (Anthracycline- Cyclophosphamide/Taxane) and Anastrozole are considered to have a significant role in the adjuvant treatment of stage II-III estrogen receptor-positive breast cancer. In this study, the authors used a combination of cross-sectional, retrospective, and prospective study designs on 95 estrogen receptor-positive and Her2 receptor negative stage II-III cancer patients treated at the Hanoi Oncology Hospital from January 1, 2015, to January 1, 2020. The research aims to evaluate the results of treatment of hormone receptor-positive breast cancer with adjuvant chemotherapy regimen 4AC-4T combined with Anastrozole. Results showed that DFS (disease-free survival) rates of 1, 2, 3, 4, and 5 years were 100, 99, 94.1, 88.3, and 88.3%, respectively. OS (overall survival) rates at 2, 3, 4, and 5 years were respectively: 100, 98.1, 95.9, and 95.9%. There was a statistically significant correlation between DFS and lymph node metastasis
between stages II and III. This study exhibited that 4AC-4T and Anastrozole are effective chemotherapeutic regimens for hormone receptor-positive breast cancer.Hóa trị phác đồ 4AC-4T (Anthracycline-Cyclophosphamide/Taxane) và thuốc nội tiết Anastrozole được cho là có vai trò quan trọng trong điều trị bổ trợ bệnh ung thư vú (UTV) có thụ thể Estrogen (ER-estrogen receptor) dương tính giai đoạn II-III. Trong nghiên cứu này, các tác giả sử dụng thiết kế nghiên cứu mô tả cắt ngang, hồi cứu kết hợp tiến cứu trên 95 bệnh nhân (BN) UTV có thụ thể Estrogen dương tính và thụ thể Her2 âm tính giai đoạn II-III được điều trị tại Bệnh viện Ung bướu Hà Nội từ tháng 1/2015 đến tháng 1/2020. Mục tiêu của nghiên cứu là đánh giá kết quả điều trị UTV có thụ thể nội tiết dương tính bằng phác đồ hóa chất bổ trợ 4AC-4T kết hợp Anastrozole. Kết quả thu được cho thấy, tỷ lệ sống thêm không bệnh sau năm thứ 1, 2, 3, 4 và 5 lần lượt là 100, 99, 94,1, 88,3 và 88,3%. Sau 2 năm đầu, tỷ lệ sống thêm toàn bộ đạt 100%, sau năm thứ 3 là 98,1%, năm thứ 4 và thứ 5 là 95,9%. Sự khác biệt có ý nghĩa thống kê về thời gian sống thêm không bệnh với yếu tố tình trạng di căn hạch, yếu tố giai đoạn II và III. Qua nghiên cứu có thể kết luận, phác đồ hóa chất 4AC-4T kết hợp Anastrozole áp dụng cho các BN UTV thụ thể nội tiết dương tính trong nghiên cứu này đem lại hiệu quả đáng kể.

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