Khảo sát khả năng hạ glucose huyết của lá Xuân hoa răng (Pseuderanthemum crenulatum) trên mô hình chuột đái tháo đường bằng alloxan

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Tác giả: Thanh Hùng Bành, Thế Anh Dư, Thị Bích Dương, Ngọc Trung Dung Huỳnh, Hữu Phúc Nguyễn, Xuân Linh Nguyễn, Kim Ngọc Trì

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ Việt Nam - B, 2022

Mô tả vật lý: tr.21

Bộ sưu tập: Metadata

ID: 327747

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In this study, the hypoglycaemic effects of ethanol extracts from Pseuderanthemum crenulatum leaves were investigated. The evaluated trials included: in vitro α-glucosidase inhibitory activity
oral glucose tolerance test in normoglycemic mice
hypoglycemia in an alloxan- induced diabetic mice model, and oral toxicity assay. The results showed that the ethanol extract of P. crenulatum leaves was able to inhibit α-glucosidase enzyme at IC50=66.01 µg/ml, 1.8 times higher than acarbose control (IC50 was 122.2 µg/ml). After 21 days of using leaf extract of P. crenulatum (1 g/kg) to treat diabetic mice, the blood glucose was reduced by 42.02%. This result was equivalent to gliclazide (10 mg/kg) which reduced the blood glucose of diabetic mice by 41.78%. The oral toxicity test results at a dose of 5 g/kg equivalent to 357 g of fresh leaf/kg after 72 hours was not exhibited acute oral toxicity in mice. In summary, there is a need for more studies on the ability of P. crenulatum leaves to treat diabetes.Nghiên cứu được thực hiện nhằm khảo sát khả năng ức chế α-glucosidase, hạ glucose huyết trên chuột gây đái tháo đường bằng alloxan và độc tính cấp của cao chiết ethanol 96% lá Xuân hoa răng (Pseuderanthemum crenulatum). Kết quả cho thấy, cao ethanol lá Xuân hoa răng có khả năng ức chế α-glucosidase ở nồng độ IC50=66,01 µg/ml, mạnh hơn 1,8 lần đối chứng dương acarbose (IC50=122,2 µg/ml). Sau 21 ngày cho chuột đái tháo đường uống cao ở liều 1 g/kg thể trọng làm hạ 42,02% nồng độ glucose huyết của chuột so với ngày đầu bắt đầu điều trị, tương đương với đối chứng dương điều trị bằng gliclazide (10 mg/kg) là 41,78%. Bên cạnh đó, lá Xuân hoa răng không thể hiện độc tính qua đường uống trên chuột ở liều 5 g/kg (tương đương với 357 g lá tươi/kg thể trọng) sau 72 giờ quan sát. Như vậy, lá Xuân hoa răng có thể sử dụng trong ổn định glucose huyết và cần có thêm những nghiên cứu kiểm chứng để

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