Xác định Topotype và so sánh di truyền virus lở mồm long móng từ heo bệnh trong vacxin

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Tác giả: Ngọc Hải Nguyễn, Thị Hồng Diễm Nguyễn, Thị Phương Bình Nguyễn, Trung Quân Nguyễn, Hoàng Anh Thư Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học kỹ thuật Thú y, 2020

Mô tả vật lý: tr.5

Bộ sưu tập: Metadata

ID: 330552

Thêm vào giỏ Liên kết toàn văn

Bệnh LMLM xảy ra trên heo tại Việt Nam chủ yếu là do virus LMLM thuộc serotype O. Hiệu quả củavacxin phòng bệnh LMLM không chỉ phụ thuộc vào serotype mà còn chịu ảnh hưởng của topotype của cácchủng virus LMLM. Trong năm 2019, nhiều trại heo tuy đã được tiêm phòng vacxin LMLM nhưng đàn heovẫn bị bệnh nghiêm trọng. Nghiên cứu được thực hiện với 15 chủng virus LMLM thu nhận được từ heo bị bệnhtại các trại heo thuộc một số tỉnh phía Nam Việt Nam và các chủng LMLM từ 3 loại vacxin LMLM thươngmại ở Việt Nam. Kết quả định danh và phân tích di truyền đã xác định 15/15 chủng virusthực địa trong nghiêncứu này đều thuộc SEAtopotype/dòng Mya-98, khác hoàn toàn với topotype của các chủng virus LMLM trongvacxin (ME-SA or Euro-SA). Tỷ lệ tương đồng trình tự nucleotide giữa 15 chủng virus LMLM thực địa và 3chủng virus LMLM trong vacxin ở mức thấp (78,9 – 82,5%). Kết quả nghiên cứu cho thấy, tình trạng bệnhLMLM vẫn xảy ra ở các trại heo tại Việt Nam khi đã được tiêm vacxin LMLM có thể liên quan đến sự khôngphù hợp kháng nguyên giữa chủng virus LMLM vacxin và chủng virus LMLM thực địa, do vậy và cần cónhững nghiên cứu tiếp theo về vấn đề này để có chiến lược sử dụng vacxin phù hợpThe occurrence of FMD in pigs in Viet Nam is mainly caused by FMD virus serotype O. The effectiveness of vaccines against FMD depends not only on the serotype, but also influence of topotype of the FMDV strains. In 2019, many pig farms have been vaccinated with FMD vaccine, but the pig herds were still suffered seriously with FMD. This study was conducted with 15 FMDV strains obtaining from the pig farms in some southern provinces, and FMDV strains from 3 commercial FMD vaccines. The genetic analysis showed that 15/15 field FMDV strains in this study belonged to the Mya-98/SEA topotype, it was completely different compared to the topotype of the FMDV strains from the vaccines (ME-SA or Euro-SA). The similarity level of nucleotide sequence of 15 field FMDV strains and 3 vaccine FMDV strains was low (78.9 - 82.5%). The studied result showed that FMD was still occurred in the pig farms in Viet Nam after the pigs were vaccinated with FMD vaccines. This may be related to antigen nonconformity/mismatch between field FMDV strain and vaccine FMDV strain. This issue needs to be studied further so that the strategy of using FMD vaccines will be considered appropriately.

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